Moro R, Heuguerot C, Vercelli-Retta J, Fielitz W, López J J, Roca R
Nucl Med Commun. 1984 Jan;5(1):5-12.
Alpha-fetoprotein (AFP) is taken up by developing fetal cells but not by normal adult cells. This finding together with the resemblance between fetal cells and cancer cells suggests that malignant tissue could incorporate AFP in opposition to normal tissue. In the present work, we injected mice bearing spontaneous mammary adenocarcinomas with 131I-radioiodinated AFP. The scintigraphic images obtained with a gamma camera showed that 11 out of 12 carcinomas displayed strong radiolabelling with very low activity in the surrounding normal tissues. In addition, three non-neoplastic cystic lesions were found to be negative. The future implications of this result for tumour diagnosis, as well as the possible mechanisms of AFP uptake are discussed.
甲胎蛋白（AFP）可被发育中的胎儿细胞摄取，但正常成年细胞不会摄取。这一发现连同胎儿细胞与癌细胞之间的相似性表明，恶性组织可能与正常组织相反，能够摄取AFP。在本研究中，我们给患有自发性乳腺腺癌的小鼠注射了131I放射性碘化AFP。用γ相机获得的闪烁图像显示，12个癌肿中有11个显示出强烈的放射性标记，而周围正常组织中的活性非常低。此外，发现3个非肿瘤性囊性病变呈阴性。讨论了这一结果对肿瘤诊断的未来意义以及AFP摄取的可能机制。
