Chiang C W, Barnett G
Clin Pharmacol Ther. 1984 Aug;36(2):234-8. doi: 10.1038/clpt.1984.168.
delta-9-Tetrahydrocannabinol (THC) kinetics and dynamics of self-reported psychologic "high" effect are analyzed in six subjects who smoked marijuana cigarettes of three different potencies. Correlation of the pharmacologic response to smoking a marijuana cigarette with plasma THC levels was done with compartmental models and phase plots. It was concluded that the effect compartment for psychologic high is directly coupled to the central (plasma) compartment. It was observed that effect is directly proportional to mean THC levels from approximately 1 to 4 hr after the start of smoking a marijuana cigarette.
对六名吸食三种不同效力大麻卷烟的受试者的δ-9-四氢大麻酚（THC）动力学以及自我报告的心理“兴奋”效应的动力学进行了分析。使用房室模型和相位图对吸食大麻卷烟的药理反应与血浆THC水平进行了相关性分析。得出的结论是，心理兴奋的效应室与中央（血浆）室直接相连。观察到，从开始吸食大麻卷烟后约1至4小时，效应与平均THC水平成正比。
