Ghishan F K, Greene H L, Halter S, Barnard J A, Moran J R
Hepatology. 1984 Jul-Aug;4(4):684-6. doi: 10.1002/hep.1840040420.
The majority of infants with cytomegalovirus hepatitis have resolution of the disease with little evidence of fibrosis; there are only rare instances of cirrhosis. We report an infant with cytomegalovirus hepatitis who developed portal hypertension and hematemesis at 3 months of age. Liver biopsy showed resolution of the hepatitis but the presence of noncirrhotic sinusoidal fibrosis. Because of recurrent hematemesis in spite of sclerosing therapy on two occasions, the beta antagonist propranolol was begun. Hepatic wedge pressures before and after treatment with propranolol were 13 and 7 mm Hg, respectively. The findings emphasize: (i) that cytomegalovirus hepatitis may result in noncirrhotic sinusoidal fibrosis and (ii) that propranolol may be beneficial in the management of portal hypertension secondary to noncirrhotic sinusoidal fibrosis.
大多数巨细胞病毒性肝炎婴儿的疾病可消退，几乎没有纤维化迹象；仅有罕见的肝硬化病例。我们报告一名患有巨细胞病毒性肝炎的婴儿，其在3个月大时出现门静脉高压和呕血。肝活检显示肝炎已消退，但存在非肝硬化性窦性纤维化。尽管进行了两次硬化治疗仍反复呕血，因此开始使用β受体拮抗剂普萘洛尔。普萘洛尔治疗前后的肝楔压分别为13和7 mmHg。这些发现强调：（i）巨细胞病毒性肝炎可能导致非肝硬化性窦性纤维化；（ii）普萘洛尔可能有助于治疗继发于非肝硬化性窦性纤维化的门静脉高压。
