一项利用细胞过继转移技术研究细胞介导的免疫在绵羊蓝舌病病毒感染中作用的实验。
A study of the role of cell-mediated immunity in bluetongue virus infection in sheep, using cellular adoptive transfer techniques.
作者信息
Jeggo M H, Wardley R C, Brownlie J
出版信息
Immunology. 1984 Jul;52(3):403-10.
Abstract
The transfer of thoracic duct lymphocytes from sheep inoculated 14 days, but not 7 days previously with bluetongue virus into their monozygotic twin resulted in some protection from challenge with bluetongue virus. T cell enrichment of the 14 day thoracic duct lymphocyte population resulted in a similar effect, indicating the T cell basis of the observed protection. Animals recovered from infection with bluetongue virus type 3 and which received thoracic duct lymphocytes from an identical twin recently infected with the same bluetongue virus type were protected from challenge with bluetongue type 4. These observations suggest that T lymphocytes play an important role in protection against bluetongue virus.
摘要
将14天前而非7天前接种蓝舌病病毒的绵羊的胸导管淋巴细胞转移至其同卵双胞胎体内，可使其在一定程度上抵御蓝舌病病毒的攻击。对14天的胸导管淋巴细胞群体进行T细胞富集也产生了类似效果，这表明观察到的保护作用是以T细胞为基础的。从感染3型蓝舌病病毒中恢复的动物，若接受来自最近感染相同3型蓝舌病病毒的同卵双胞胎的胸导管淋巴细胞，则可抵御4型蓝舌病病毒的攻击。这些观察结果表明，T淋巴细胞在抵御蓝舌病病毒方面发挥着重要作用。
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