用不同蓝舌病毒类型免疫小鼠后产生交叉反应性细胞毒性T淋巴细胞。
Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types.
作者信息
Jeggo M H, Wardley R C
出版信息
Immunology. 1982 Apr;45(4):629-35.
Abstract
Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.
摘要
用单一型蓝舌病（BT）病毒免疫的小鼠被证明能产生与多种BT病毒类型发生交叉反应的细胞毒性T淋巴细胞（CTL）。这些交叉反应性CTL可通过体内初次刺激和体外二次刺激诱导产生。在所检测的六种BT病毒类型中出现了不同程度的交叉反应。研究了这种交叉反应性的特征，并讨论了其在预防疾病和疫苗接种策略中的作用。
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