Micusan V V, Borduas A G
Immunology. 1977 Apr;32(4):373-81.
Ther serum concentration of normal adult goat total IgG was established to be 19.97 +/- 1.55 mg/ml, the IgG1 10.92 +/- 0.84 mg/ml and IgG2 9.07 +/- 0.78 mg/ml. No significant variations were found to be associated with the seasons of the year but changes in concentration, especially in serum IgG1 occur ante- and post-partum. In goat colostrum, the IgG concentration is about 2.4-2.8 times greater than in serum and the IgG1 subclass accounts for 95-98 per cent. During the immune response the IgG1 rises sharply whereas variations in IgG2 concentration are less evident. Both IgG subclasses are active in haemagglutination, although the IgG1 is 22-52 times more efficient. As in all ruminants, only IgG1 fixes complement in the classical test. Differences exist between IgG subclasses in their ability to induce PCA reactions. IgG2 subclass is active only in homologous species whereas the IgGl in heterologous species. Cytophilic activity is associated with IgG2 subclass.
正常成年山羊血清中总IgG的浓度确定为19.97±1.55mg/ml，IgG1为10.92±0.84mg/ml，IgG2为9.07±0.78mg/ml。未发现与一年中的季节有显著相关性，但浓度会发生变化，尤其是血清IgG1在产前和产后会出现变化。在山羊初乳中，IgG浓度比血清中约高2.4 - 2.8倍，且IgG1亚类占95 - 98%。在免疫反应期间，IgG1急剧上升，而IgG2浓度的变化不太明显。两种IgG亚类在血凝反应中均有活性，尽管IgG1的效率高22 - 52倍。与所有反刍动物一样，在经典试验中只有IgG1能固定补体。IgG亚类在诱导PCA反应的能力上存在差异。IgG2亚类仅在同源物种中具有活性，而IgG1在异源物种中具有活性。亲细胞活性与IgG2亚类相关。
