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巴西日圆线虫在大鼠体内的感染。驱虫所需的细胞条件。

Nippostrongylus brasiliensis infection in rats. The cellular requirement for worm expulsion.

作者信息

Ogilvie B M, Love R J, Jarra W, Brown K N

出版信息

Immunology. 1977 Apr;32(4):521-8.

PMID:608681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445492/
Abstract

The expulsion of antibody-damaged Nippostrongylus brasiliensis nematodes from the intestine of rats irradiated with 750 rad 60Co was induced by thoracic duct lymph (TDL) or mesenteric lymph node (MLN) cells apparently without the help of bone marrow-derived cells. The effector cells were present in the TDL or MLN of rats by the 8th day after infection and could be recovered from the peritoneal cavity. The ability of TDL cells to transfer immunity to irradiated recipients was undiminished when the cells with immunoglobulin on their surface were removed. These results suggest that, following antibody damage, this nematode is expelled by nonimmunoglobulin-bearing lymphocytes which are effective in the absence of newly formed cells derived from the cell recipients.

摘要

经750拉德60钴照射的大鼠肠道中，抗体损伤的巴西日圆线虫的排出是由胸导管淋巴（TDL）或肠系膜淋巴结（MLN）细胞诱导的，显然无需骨髓来源细胞的帮助。感染后第8天，效应细胞存在于大鼠的TDL或MLN中，并且可以从腹腔中回收。当去除表面带有免疫球蛋白的细胞时，TDL细胞将免疫力转移给受照射受体的能力并未减弱。这些结果表明，在抗体损伤后，这种线虫被不携带免疫球蛋白的淋巴细胞排出，这些淋巴细胞在没有来自受体细胞的新形成细胞的情况下仍然有效。

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本文引用的文献

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The oxidation of pyruvate in pigeon breast muscle.鸽胸肌中丙酮酸的氧化作用。
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Effects of immunity of Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction, and morphology.巴西日圆线虫成虫免疫的影响：感染力、繁殖力及形态的可逆和不可逆变化
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The cellular transfer to immunity to Nippostrongylus brasiliensis in inbred rats (Lewis strain).近交系大鼠（Lewis品系）对巴西日圆线虫免疫的细胞转移
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Protective immunity to Nippostrongylus brasiliensis in the rat. Central role of the lymphocyte in worm expulsion.大鼠对巴西日圆线虫的保护性免疫。淋巴细胞在驱虫中的核心作用。
Immunology. 1972 May;22(5):767-73.
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Cells mediating specific in vitro cytotoxicity. II. Probable autonomy of thymus-processed lymphocytes (T cells) for the killing of allogeneic target cells.介导特异性体外细胞毒性的细胞。II. 经胸腺处理的淋巴细胞（T细胞）杀伤同种异体靶细胞可能具有自主性。
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