通过血清和细胞传递小鼠对大鼠类圆线虫感染的抵抗力。
Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice.
作者信息
Dawkins H J, Grove D I
出版信息
Immunology. 1981 Jun;43(2):317-22.
Abstract
C57Bl/6 mice were infected with Strongyloides ratti. Susceptibility to infection was ascertained by quantifying the numbers of larvae in the faeces 1 week after infection. Resistance to infection was transferred by pooled immune serum and mesenteric lymph node (MLN) cells obtained 2 and 3 weeks after infection. There was no additive effect when immune serum and MLN cells were given together. Protection was not conferred by MLN cells 1, 4 or 6 weeks after infection nor by spleen cells taken 1--6 weeks after infection. There was, however, a mild non-specific reduction in larval excretion after transfer of either normal or immune spleen cells. These data indicate that both humoral and cell-mediated immune responses may confer resistance to infection in murine strongyloidiasis.
摘要
将C57Bl/6小鼠感染鼠类圆线虫。通过量化感染后1周粪便中的幼虫数量来确定感染易感性。感染后2周和3周获得的混合免疫血清和肠系膜淋巴结（MLN）细胞可传递抗感染能力。当免疫血清和MLN细胞同时给予时，没有相加效应。感染后1、4或6周的MLN细胞以及感染后1 - 6周获取的脾细胞均不能提供保护作用。然而，正常或免疫脾细胞转移后，幼虫排泄有轻度非特异性减少。这些数据表明，体液免疫和细胞介导的免疫反应均可赋予小鼠类圆线虫病抗感染能力。
相似文献
1
Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice.
Immunology. 1981 Jun;43(2):317-22.
2
Intestinal protection against Strongyloides ratti and mastocytosis induced by administration of interleukin-3 in mice.
Immunology. 1993 Sep;80(1):116-21.
3
Passive immunization with a monoclonal IgM antibody specific for Strongyloides ratti HSP60 protects mice against challenge infection.
Vaccine. 2012 Jul 13;30(33):4971-6. doi: 10.1016/j.vaccine.2012.05.046. Epub 2012 May 30.
4
Transfer of immunity against Strongyloides ratti (Nematoda) using immune spleen cells.
J Parasitol. 1984 Feb;70(1):187-9.
5
Evaluation of the immune response against Strongyloides venezuelensis in antigen-immunized or previously infected mice.
Parasite Immunol. 2008 Mar;30(3):139-49. doi: 10.1111/j.1365-3024.2007.01009.x. Epub 2007 Dec 18.
6
Adoptive transfer of protective immunity in experimental schistosomiasis in the mouse.
J Parasitol. 1979 Aug;65(4):515-9.
7
Pattern of immune response in recipients after transfer of mesenteric lymph node cells sensitized with low and high doses of Ancylostoma caninum.
Folia Parasitol (Praha). 1983;30(3):285-8.
8
Infection of mice with Nematospiroides dubius: demonstration of neutrophil-mediated immunity in vivo in the presence of antibodies.
Immunology. 1984 Sep;53(1):147-54.
9
Analysis of T cell populations and IL-3 mRNA expression in mesenteric lymph node cells and intestinal intraepithelial lymphocytes in Strongyloides ratti-infected mice.
J Helminthol. 1998 Mar;72(1):1-8. doi: 10.1017/s0022149x00000894.
10
Transfer of immunity against Hymenolepis nana in mice with lymphoid cells or serum from infected donors.
Parasitology. 1984 Oct;89 ( Pt 2):287-93. doi: 10.1017/s0031182000001311.
引用本文的文献
1
infection in mice: immune response and immune modulation.
Philos Trans R Soc Lond B Biol Sci. 2024 Jan 15;379(1894):20220440. doi: 10.1098/rstb.2022.0440. Epub 2023 Nov 27.
2
IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection.
Infect Immun. 2013 Jul;81(7):2518-27. doi: 10.1128/IAI.00285-13. Epub 2013 Apr 29.
3
Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.
Immunol Res. 2011 Dec;51(2-3):205-14. doi: 10.1007/s12026-011-8258-2.
4
Mucosal immunity against parasitic gastrointestinal nematodes.
Korean J Parasitol. 2000 Dec;38(4):209-36. doi: 10.3347/kjp.2000.38.4.209.
5
Light and electron microscopical studies of the location of Strongyloides ratti in the mouse intestine.
Z Parasitenkd. 1983;69(3):357-70. doi: 10.1007/BF00927877.
6
Immunologic responses to experimental strongyloidiasis in rats.
Z Parasitenkd. 1983;69(5):667-75. doi: 10.1007/BF00926676.
7
IgE response in Strongyloides ratti-infected rats with special reference to the life cycle of the parasite.
Z Parasitenkd. 1986;72(2):213-20. doi: 10.1007/BF00931148.
8
Immunological aspects of murine infection with the rat nematode Strongyloides ratti Sandground, 1925.
Z Parasitenkd. 1986;72(4):493-509. doi: 10.1007/BF00927893.
本文引用的文献
1
Strongyloides ratti: susceptibility to infection and resistance to reinfection in inbred strains of mice as assessed by excretion of larvae.
Int J Parasitol. 1980 Apr;10(2):125-9. doi: 10.1016/0020-7519(80)90023-5.
2
Strongyloides ratti: structural and functional characteristics of normal and immune-damaged worms.
Exp Parasitol. 1980 Apr;49(2):139-52. doi: 10.1016/0014-4894(80)90112-5.
3
Transfer of immunity against Trichuris muris in the mouse by serum and cells.
Int J Parasitol. 1973 Nov;3(6):717-22. doi: 10.1016/0020-7519(73)90062-3.
4
Co-operation between antibodies and cells in immunity to a nematode parasite.
Transplant Rev. 1974;19(0):147-69. doi: 10.1111/j.1600-065x.1974.tb00131.x.
5
Mechanisms of immunity to intestinal helminths.
Aust Vet J. 1973 Feb;49(2):91-7. doi: 10.1111/j.1751-0813.1973.tb09323.x.
6
Thymus-dependency of the immune response of mice to a primary infection with the nematode Trichuris muris.
Int J Parasitol. 1974 Dec;4(6):657-61. doi: 10.1016/0020-7519(74)90030-7.
7
Immune response to Trichinella spiralis in the rat. I. Development of cellular and humoral responses during chronic infection.
Int Arch Allergy Appl Immunol. 1975;49(3):396-410.
8
Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors.
Parasitology. 1976 Jun;72(3):307-15. doi: 10.1017/s0031182000049507.
9
Transfer of immunity to Trichinella spiralis in the mouse with mesenteric lymph node cells: time of appearance of effective cells in donors and expression of immunity in recipients.
Parasitology. 1977 Jun;74(3):215-24. doi: 10.1017/s0031182000047843.
10
Immunity to intestinal parasites.
Nature. 1978 Jun 22;273(5664):617-20. doi: 10.1038/273617a0.
Zotero 插件