帕金森病患者黑质和尾状核中的脑啡肽能标志物。
Enkephalinergic markers in substantia nigra and caudate nucleus from Parkinsonian subjects.
作者信息
Llorens-Cortes C, Javoy-Agid F, Agid Y, Taquet H, Schwartz J C
出版信息
J Neurochem. 1984 Sep;43(3):874-7. doi: 10.1111/j.1471-4159.1984.tb12812.x.
Abstract
Marked reductions in opiate receptor binding (-42%), "enkephalinase" activity (-39%), and Met5-enkephalin levels (-72%) accompanied the well-established dopamine depletion in the substantia nigra pars compacta of Parkinsonian subjects. In contrast, enkephalinergic markers were not significantly modified in caudate nucleus.
摘要
帕金森病患者黑质致密部中，明显的阿片受体结合减少（-42%）、“脑啡肽酶”活性降低（-39%）以及甲硫氨酸脑啡肽水平下降（-72%）与多巴胺耗竭密切相关。相比之下，尾状核中的脑啡肽能标志物没有显著改变。
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