Bokobza B, Ruberg M, Scatton B, Javoy-Agid F, Agid Y
Eur J Pharmacol. 1984 Mar 23;99(2-3):167-75. doi: 10.1016/0014-2999(84)90238-3.
The density of D2-type dopamine receptors, measured by the binding of [3H]spiperone was normal in the substantia nigra, caudate nucleus and nucleus accumbens of Parkinsonian subjects and above control levels in the putamen, in spite of massive lesions of the dopaminergic neurons. Dopamine levels were reduced in the putamen, caudate nucleus, and nucleus accumbens by 97, 85 and 68%, respectively and by 78 and 93% in the pars compacta and pars reticulata of the substantia nigra. HVA levels were much less affected suggesting that increased activity of the remaining dopaminergic neurons compensated to some extent for the lesions. Neuroleptic treatment and the presence of dementia in the Parkinsonian subjects affected [3H]spiperone binding and dopamine concentrations. Dopamine and HVA levels in the striatum of subjects with supranuclear palsy indicate that the nigrostriatal system was lesioned to the same degree in this disease as in idiopathic Parkinsonism, but spiperone binding was reduced by half in all the structures studies.
通过[3H]螺哌隆结合法测定，尽管多巴胺能神经元有大量损伤，但帕金森病患者黑质、尾状核和伏隔核中D2型多巴胺受体的密度正常，壳核中的受体密度高于对照水平。壳核、尾状核和伏隔核中的多巴胺水平分别降低了97%、85%和68%，黑质致密部和网状部中的多巴胺水平分别降低了78%和93%。高香草酸（HVA）水平受影响较小，这表明剩余多巴胺能神经元活性增加在一定程度上补偿了损伤。帕金森病患者的抗精神病药物治疗和痴呆的存在影响了[3H]螺哌隆结合和多巴胺浓度。核上性麻痹患者纹状体中的多巴胺和HVA水平表明，在这种疾病中黑质纹状体系统的损伤程度与特发性帕金森病相同，但在所有研究的结构中，螺哌隆结合减少了一半。
