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IgE介导的反应对大鼠迟发型超敏反应表达的影响。

The influence of IgE-mediated reactions on the expression of delayed hypersensitivity in the rat.

作者信息

Pearson D J, Taylor G

出版信息

Immunology. 1977 Aug;33(2):185-90.

PMID:608685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445348/
Abstract

The effect of IgE-mediated reactions on the expression of delayed hypersensitivity skin reactions was examined in the rat. It was found that the elicitation of an IgE-mediated reaction at the time of skin test could either potentiate or inhibit the development of delayed reactions. At a fixed level of IgE sensitivity, large delayed reactions were potentiated and small delayed reactions suppressed. These interactions were not dependent on the two types of sensitivity being direct against the same antigen but were dependent on the reaction of IgE with its appropriate antigen.

摘要

在大鼠中研究了IgE介导的反应对迟发型超敏皮肤反应表达的影响。结果发现，在皮肤试验时引发IgE介导的反应可增强或抑制迟发型反应的发展。在固定的IgE敏感性水平下，大的迟发型反应增强，小的迟发型反应受到抑制。这些相互作用并不取决于两种敏感性是否直接针对同一抗原，而是取决于IgE与其相应抗原的反应。

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本文引用的文献

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Potentiated reagin response to egg albumin in Nippostrongylus brasiliensis infected rats. II. Time course of the reagin response.巴西日圆线虫感染大鼠对卵清蛋白的致敏反应增强。II. 致敏反应的时间进程。
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Selective depletion of lymphoid tissue by cyclophosphamide.用环磷酰胺选择性地消耗淋巴组织。
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Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.无反应小鼠的T细胞对接触敏感性T细胞现象的抑制作用。
Nature. 1973 Jul 27;244(5413):227-8. doi: 10.1038/244227a0.
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Br J Pharmacol Chemother. 1966 Aug;27(2):427-39. doi: 10.1111/j.1476-5381.1966.tb01674.x.
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