Koepp P
Monatsschr Kinderheilkd. 1984 May;132(5):264-7.
Transitory Lactic acidemia may be found under very different conditions, eg. hyperventilation, hypoxia, strenuous muscular work, diabetic ketoacidosis, malignancies and totally parenteral alimentation. In contrast chronic, permanent lactic acidemia and lactic aciduria may point to one of several and usually severe inherited metabolic diseases of gluconeogenesis, pyruvate oxidation, the Krebs cycle or the respiratory chain. Clinical hints for a stepwise differential diagnosis are presented.
短暂性乳酸血症可能在非常不同的情况下出现,例如换气过度、缺氧、剧烈肌肉运动、糖尿病酮症酸中毒、恶性肿瘤以及全胃肠外营养。相比之下,慢性、持续性乳酸血症和乳酸性尿症可能提示糖异生、丙酮酸氧化、三羧酸循环或呼吸链等几种通常较为严重的遗传性代谢疾病之一。本文给出了逐步进行鉴别诊断的临床提示。