Walker F O, Young A B, Penney J B, Dovorini-Zis K, Shoulson I
Neurology. 1984 Sep;34(9):1237-40. doi: 10.1212/wnl.34.9.1237.
We compared autoradiographic measurements of GABA and benzodiazepine receptors in the brains of two early cases of Huntington's disease (HD), five controls, and four advanced cases of HD. These receptors increase in lateral globus pallidus and decrease in putamen early in the disease, before there is any extensive cell loss and atrophy. The cause of these receptor changes is unknown, but could imply dysfunction rather than death of striatal neurons.
我们比较了2例早期亨廷顿舞蹈症（HD）患者、5例对照者以及4例晚期HD患者大脑中γ-氨基丁酸（GABA）和苯二氮䓬受体的放射自显影测量结果。在疾病早期，在出现广泛细胞丢失和萎缩之前，这些受体在外侧苍白球中增加，而在壳核中减少。这些受体变化的原因尚不清楚，但可能意味着纹状体神经元功能障碍而非死亡。
