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果蝇核糖体蛋白49基因的序列、结构及密码子偏好性

Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene.

作者信息

O'Connell P O, Rosbash M

出版信息

Nucleic Acids Res. 1984 Jul 11;12(13):5495-513. doi: 10.1093/nar/12.13.5495.

DOI:10.1093/nar/12.13.5495
PMID:6087289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318935/
Abstract

In this communication, we describe several features of the D. melanogaster gene which codes for ribosomal protein 49 (rp49). Nucleotide sequence analysis in conjunction with primer extension and S1 nuclease protection experiments show that the structure of the rp49 gene consists of a 102 bp 5' exon, a single 59 bp intron, and a 420 bp 3' exon, encoding a total of 132 amino acids. The rp49 gene shares many features with other abundantly expressed Drosophila genes, including codon preference, which are discussed.

摘要

在本通讯中，我们描述了果蝇中编码核糖体蛋白49（rp49）的基因的几个特征。核苷酸序列分析结合引物延伸和S1核酸酶保护实验表明，rp49基因的结构由一个102 bp的5'外显子、一个59 bp的单一内含子和一个420 bp的3'外显子组成，总共编码132个氨基酸。rp49基因与其他大量表达的果蝇基因具有许多共同特征，包括密码子偏好性，对此进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/10482e48b4d8/nar00331-0358-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/0612f43f65fe/nar00331-0351-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/4392ec757e3c/nar00331-0352-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/078bd9ec721f/nar00331-0356-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/10482e48b4d8/nar00331-0358-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/0612f43f65fe/nar00331-0351-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/4392ec757e3c/nar00331-0352-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/078bd9ec721f/nar00331-0356-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74e/318935/10482e48b4d8/nar00331-0358-a.jpg

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