一个五十年的个人历程：位置、基因表达和昼夜节律。
A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms.
机构信息
Howard Hughes Medical Institute, National Center for Behavioral Genomics and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
出版信息
Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12):a032516. doi: 10.1101/cshperspect.a032516.
I worked almost exclusively on nucleic acids and gene expression from the age of 19 as an undergraduate until the age of 38 as an associate professor. Mentors featured prominently in my choice of paths. My friendship with influential Brandeis colleagues then persuaded me that genetics was an important tool for studying gene expression, and I switched my experimental organism to yeast for this reason. Several years later, friendship also played a prominent role in my beginning work on circadian rhythms. As luck would have it, gene expression as well as genetics turned out to be important for circadian timekeeping. As a consequence, background and training put my laboratory in an excellent position to contribute to this aspect of the circadian problem. The moral of the story is, as in real estate, "location, location, location."
我从 19 岁的本科生时代到 38 岁的副教授时代，几乎一直在从事核酸和基因表达方面的工作。导师在我选择的道路上扮演了重要的角色。我与有影响力的布兰迪斯同事的友谊使我相信遗传学是研究基因表达的重要工具，出于这个原因，我将我的实验生物切换到了酵母。几年后，友谊在我开始研究生物钟时也扮演了重要的角色。碰巧的是，基因表达以及遗传学对于生物钟计时也很重要。因此，背景和培训使我的实验室能够在这个生物钟问题的方面做出重要贡献。这个故事的寓意是，就像房地产一样，“位置，位置，位置”。
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