Kilfeather S A, Massarella A, Gorgolewska G, Ansell E, Turner P
Postgrad Med J. 1984 Jun;60(704):391-3. doi: 10.1136/pgmj.60.704.391.
Beta-adrenoceptor blocking drugs are of prophylactic value in some patients with migraine. Beta-adrenoceptor responsiveness as measured by lymphocyte cAMP responsiveness to isoprenaline has, therefore, been compared in ten untreated classical migraine patients and ten matched non-migraine control subjects. Lymphocyte responsiveness to epoprostenol (prostacyclin, PGI2) was also compared. No difference in response to either agent was found between the two groups. A generalized abnormality of beta-adrenoceptor function does not appear to be present in classical migraine, but a defect localized to specific vascular regions cannot be excluded.
β-肾上腺素受体阻断药对一些偏头痛患者具有预防作用。因此，对10名未经治疗的典型偏头痛患者和10名匹配的非偏头痛对照受试者的淋巴细胞环磷酸腺苷（cAMP）对异丙肾上腺素的反应性所测定的β-肾上腺素受体反应性进行了比较。还比较了淋巴细胞对依前列醇（前列环素，PGI2）的反应性。两组对这两种药物的反应均未发现差异。典型偏头痛患者似乎不存在β-肾上腺素受体功能的普遍异常，但不能排除特定血管区域存在缺陷的可能性。
