Kuritzky A, Bennet E, Hering R, Ebstein R
Department of Neurology, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, Petach-Tikva, Israel.
Headache. 1993 Apr;33(4):198-200. doi: 10.1111/j.1526-4610.1993.hed33040198.x.
Cyclic AMP (CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin-induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta-adrenergic receptor sensitivity. An alteration in lymphocyte beta-adrenergic receptor may reflect similar changes in central beta-adrenergic function and may be used as a probe to evaluate its activity.
在12例偏头痛患者和12名健康对照者中，测定了异丙肾上腺素（IP）和福斯高林在完整淋巴细胞中诱导的环磷酸腺苷（CAMP）积累。我们的数据显示，IP诱导的CAMP积累（8.20±1.08皮摩尔/百万细胞）显著低于对照组（14.39±2.44皮摩尔/百万细胞）（P = 0.033）。两组中福斯高林诱导的CAMP没有差异。这些发现支持偏头痛与淋巴细胞β-肾上腺素能受体敏感性降低之间的关联。淋巴细胞β-肾上腺素能受体的改变可能反映中枢β-肾上腺素能功能的类似变化，并可作为评估其活性的探针。
