降钙素可增强受刺激的人单核细胞产生前列腺素的能力。
Calcitonin enhances production of prostaglandins by stimulated human monocytes.
作者信息
Stock J L, Coderre J A
出版信息
Prostaglandins. 1984 May;27(5):771-9. doi: 10.1016/0090-6980(84)90014-5.
Stimulated monocytes produce prostaglandins that may play a role in bone resorption. We studied the effects of salmon calcitonin (sCT) on human monocyte production of various prostaglandin metabolites. Latex particle-stimulated human monocyte production of prostaglandin E2, thromboxane A2 measured as thromboxane B2, and prostacyclin measured as 6-keto-PGF1 alpha was each increased in the presence of sCT. This effect required surface stimulation, was blocked by indomethacin, was less marked with equivalent concentrations of human calcitonin, and was not seen with parathyroid hormone. Calcitonin specifically affects prostaglandin pathways in stimulated human monocytes.
受刺激的单核细胞会产生可能在骨吸收中起作用的前列腺素。我们研究了鲑鱼降钙素（sCT）对人单核细胞产生各种前列腺素代谢产物的影响。在sCT存在的情况下，乳胶颗粒刺激的人单核细胞产生的前列腺素E2、以血栓素B2衡量的血栓素A2以及以6-酮-前列腺素F1α衡量的前列环素均增加。这种作用需要表面刺激，可被吲哚美辛阻断，同等浓度的人降钙素作用则较弱，而甲状旁腺激素无此作用。降钙素特异性地影响受刺激的人单核细胞中的前列腺素途径。
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