Genazzani A R, Petraglia F, Facchinetti F, Facchini V, Volpe A, Alessandrini G
Am J Obstet Gynecol. 1984 Aug 1;149(7):775-9. doi: 10.1016/0002-9378(84)90121-2.
The present study reports the plasma levels of gonadotropins (luteinizing hormone, follicle-stimulating hormone), proopiomelanocortin-related peptides (adrenocorticotropic hormone, beta-endorphin, and beta-lipotropin), and cortisol in eight menopausal women experiencing frequent hot flushes. beta-Endorphin and beta-lipotropin levels were measured by radioimmunoassay after extraction and Sephadex G-75 column chromatography. Plasma levels of adrenocorticotropic hormone (after extraction), luteinizing hormone, follicle-stimulating hormone, and cortisol were measured by specific radioimmunoassay. All hormone levels showed a prompt and significant rise on occurrence of hot flushes (18 total recordings), remained high for 15 minutes, and decreased to basal levels 35 minutes later. The evaluation of the behavior pattern of single hormone levels revealed a more pronounced increase of proopiomelanocortin-related peptides and cortisol than of gonadotropins (p less than 0.01).
本研究报告了8名频繁出现潮热的绝经后女性的促性腺激素（黄体生成素、卵泡刺激素）、阿片-促黑素细胞皮质素原相关肽（促肾上腺皮质激素、β-内啡肽和β-促脂解素）以及皮质醇的血浆水平。β-内啡肽和β-促脂解素水平在提取和经葡聚糖凝胶G-75柱层析后通过放射免疫测定法进行测量。促肾上腺皮质激素（提取后）、黄体生成素、卵泡刺激素和皮质醇的血浆水平通过特定放射免疫测定法进行测量。在潮热发作时（共18次记录），所有激素水平均迅速且显著升高，持续15分钟保持高位，35分钟后降至基础水平。对单一激素水平行为模式的评估显示，阿片-促黑素细胞皮质素原相关肽和皮质醇的升高比促性腺激素更为明显（p<0.01）。
