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男性乳腺癌中的激素受体

Hormone receptors in male breast cancer.

作者信息

Mercer R J, Bryan R M, Bennett R C

出版信息

Aust N Z J Surg. 1984 Jun;54(3):215-8. doi: 10.1111/j.1445-2197.1984.tb05305.x.

DOI:10.1111/j.1445-2197.1984.tb05305.x
PMID:6087783
Abstract

Hormone receptor assays were performed on specimens of breast cancer from 19 male patients over a six year period. Ninety-four per cent were positive for oestrogen receptor, 93% for progesterone receptor and 57% for androgen receptor. Eight patients had hormonal treatment for advanced disease and five (62.5%) responded. Duration of response ranged from six months to 23 months. There appeared to be no clear relationship between hormone receptor status or quantitative receptor level and response to treatment in this small series. It is unlikely that oestrogen and progesterone receptors will be of value as discriminators because of their high incidence and it is suggested that further study of androgen receptor is indicated.

摘要

在六年时间里,对19例男性乳腺癌患者的标本进行了激素受体检测。94%的患者雌激素受体呈阳性,93%的患者孕激素受体呈阳性,57%的患者雄激素受体呈阳性。8例晚期疾病患者接受了激素治疗,其中5例(62.5%)有反应。反应持续时间从6个月到23个月不等。在这个小样本系列中,激素受体状态或定量受体水平与治疗反应之间似乎没有明显关系。由于雌激素和孕激素受体的高发生率,它们作为鉴别指标的价值不大,建议对雄激素受体进行进一步研究。

相似文献

1
Hormone receptors in male breast cancer.男性乳腺癌中的激素受体
Aust N Z J Surg. 1984 Jun;54(3):215-8. doi: 10.1111/j.1445-2197.1984.tb05305.x.
2
Hormone receptor levels and aspiration cytology in cancer of the breast.乳腺癌中的激素受体水平与针吸细胞学检查
Am J Clin Pathol. 1982 Dec;78(6):847-9. doi: 10.1093/ajcp/78.6.847.
3
[Function mechanism of steroid hormones and their receptor assay].[类固醇激素的作用机制及其受体测定]
Rinsho Byori. 1982 Nov;Suppl 52:40-54.
4
[New data on relations between residual hormonal modulability and medical treatment of breast adenocarcinoma].[关于残余激素可调节性与乳腺腺癌医学治疗之间关系的新数据]
Minerva Med. 1984 Feb 18;75(6):219-21.
5
Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer.人乳腺癌中雌激素、孕激素、雄激素和糖皮质激素受体的分布、频率及定量分析。
Cancer Res. 1979 May;39(5):1447-54.
6
[Breast cancer and hormone receptors (author's transl)].
Horumon To Rinsho. 1980 Jan;28(1):29-37.
7
Hormone-receptor assays in breast cancer. A five-year experience.乳腺癌中的激素受体检测。五年经验总结。
Med J Aust. 1983 Apr 16;1(8):365-9.
8
Steroid hormone receptors in male breast diseases.男性乳腺疾病中的类固醇激素受体
Anticancer Res. 1986 Sep-Oct;6(5):1013-7.
9
[The hormonal therapy and steroid receptor analysis in advanced carcinoma of the breast (author's transl)].晚期乳腺癌的激素治疗与类固醇受体分析(作者译)
Geburtshilfe Frauenheilkd. 1979 Mar;39(3):177-86.
10
Quantitative oestrogen and progesterone receptor values in primary breast cancer and predictability of response to endocrine therapy.原发性乳腺癌中雌激素和孕激素受体的定量值及内分泌治疗反应的可预测性
Clin Oncol. 1983 Sep;9(3):245-50.

引用本文的文献

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Estrogen receptor content in malignant breast tumors in men--a review.男性恶性乳腺肿瘤中的雌激素受体含量——综述
J Mammary Gland Biol Neoplasia. 2000 Jul;5(3):283-7. doi: 10.1023/a:1009546811429.
2
Androgen receptor expression in male breast carcinoma: lack of clinicopathological association.雄激素受体在男性乳腺癌中的表达:缺乏临床病理相关性。
Br J Cancer. 1999 Feb;79(5-6):959-64. doi: 10.1038/sj.bjc.6690153.
3
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