Paradisi L, Panagini C, Negro F, Parola M, Torrielli M V
Cell Biochem Funct. 1984 Apr;2(2):111-4. doi: 10.1002/cbf.290020211.
The content of hepatic cyclic AMP was increased soon after intoxication by white phosphorus. Its level reached a maximum 4 h after poisoning, but in subsequent phases tended to return to normal. In contrast, the cyclic GMP concentration was altered only 24 and 36 h after treatment with the same hepatotoxin. Similar modifications of cAMP and cGMP content were also detected after poisoning by trichlorobromomethane (CBrCl3). As a consequence, an altered cGMP/cAMP ratio was found in both experimental conditions. Further, the modification of cAMP content after white phosphorus was detected prior to liver damage (steatosis and necrosis), while the highest concentration of the cyclic nucleotide in CBrCl3-poisoned rats was found when fatty liver was already evident. In addition, in phosphorus-poisoned rats, the hepatic content of Ca2+ was found to be unmodified during all phases of the intoxication, while after CBrCl3 a phasic increase of the Ca2+ level was observed at 4, 24 and 36 h.
白磷中毒后不久，肝脏中环磷酸腺苷（cAMP）的含量就会增加。中毒4小时后其水平达到最高，但在随后阶段趋于恢复正常。相比之下，环磷酸鸟苷（cGMP）浓度仅在使用相同肝毒素处理24小时和36小时后发生改变。三氯溴甲烷（CBrCl3）中毒后也检测到cAMP和cGMP含量有类似变化。因此，在两种实验条件下均发现cGMP/cAMP比值发生改变。此外，白磷中毒后cAMP含量的变化在肝脏损伤（脂肪变性和坏死）之前就已检测到，而在CBrCl3中毒大鼠中，当脂肪肝已经明显时发现环核苷酸浓度最高。此外，在磷中毒大鼠中，在中毒的所有阶段肝脏中Ca2+含量均未改变，而在CBrCl3中毒后，在4小时、24小时和36小时观察到Ca2+水平呈阶段性升高。
