Sano M
Acta Pathol Jpn. 1976 Jul;26(4):423-33. doi: 10.1111/j.1440-1827.1976.tb00500.x.
Acute serum sickness in the rabbit was studied with special reference to the role of monocytes in the inflammatory process in the glomerulus. It was revealed that macrophages were the major factor in producing glomerular hypercellularity in acute serum sickness. Proliferation of intrinsic glomerular cells or accumulation of polymorphonuclear leukocytes (PMNs) was minimal. Ultrastructural characteristics of these phagocytic cells were described. Macrophages engulfed various inflammatory products such as fibrin and cell debri in the glomerular capillary. Colloidal carbon administered at the active inflammatory stage was found to be mostly engulfed by macrophages, little by mesangial cells, and was not seen in endothelial or epithelial cells and PMNs. The selective ingestion of the carbon particles by these macrophages made it possible to differentiate them from glomerular cells. This in turn indicated that the macrophages were derived from neither endothelial nor menangial cells and that they were of blood monocytic origin. It was suggested that monocytic cells participated in glomerular inflammation but they, on the other hand, contributed to the repair of glomerular injuries through their active role for phagocytosis.
对兔急性血清病进行了研究，特别关注单核细胞在肾小球炎症过程中的作用。结果显示，巨噬细胞是急性血清病中导致肾小球细胞增多的主要因素。固有肾小球细胞的增殖或多形核白细胞（PMN）的积聚极少。描述了这些吞噬细胞的超微结构特征。巨噬细胞吞噬肾小球毛细血管中的各种炎症产物，如纤维蛋白和细胞碎片。发现在炎症活跃期给予的胶体碳大多被巨噬细胞吞噬，系膜细胞吞噬较少，在内皮细胞、上皮细胞和PMN中未见。这些巨噬细胞对碳颗粒的选择性摄取使其能够与肾小球细胞区分开来。这反过来表明，巨噬细胞既不是来源于内皮细胞也不是系膜细胞，而是来源于血液中的单核细胞。提示单核细胞参与肾小球炎症，但另一方面，它们通过积极的吞噬作用有助于肾小球损伤的修复。
