一项针对在职人群乙肝表面抗原携带者的前瞻性队列研究。
A prospective cohort study of hepatitis B surface antigen carriers in a working population.
作者信息
Iijma T, Saitoh N, Nobutomo K, Nambu M, Sakuma K
出版信息
Gan. 1984 Jul;75(7):571-3.
PMID:6088348
Abstract
A 10-year prospective cohort study was made of 495 male hepatitis B surface antigen (HBsAg) carriers aged over 40 at entry. The observed/expected mortality rate ratio of primary liver cancer (PLC) was 10.40, based on the general population in Japan. The annual incidence rate of PLC (including 2 survivals) was 365/100,000 person-years. All histologically confirmed cases of PLC were hepatocellular carcinoma (HCC). The chronic HBsAg carrier state is suggested to be a risk factor of HCC.
摘要
对495名入组时年龄超过40岁的男性乙肝表面抗原（HBsAg）携带者进行了一项为期10年的前瞻性队列研究。基于日本普通人群，原发性肝癌（PLC）的观察/预期死亡率比为10.40。PLC的年发病率（包括2例存活者）为365/100,000人年。所有经组织学确诊的PLC病例均为肝细胞癌（HCC）。慢性HBsAg携带状态被认为是HCC的一个危险因素。
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