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肉碱和乙酰肉碱对中枢神经系统作用的药理学概况。

A pharmacological profile of the effects of carnitine and acetyl carnitine on the central nervous system.

作者信息

Janiri L, Tempesta E

出版信息

Int J Clin Pharmacol Res. 1983;3(4):295-306.

PMID:6088408
Abstract

In this pharmacological study the authors give an extensive review of existing literature regarding the activity of carnitine and acetyl carnitine on the central nervous system. Carnitine and acetyl carnitine enter the neuro-biochemical patterns in the endoneuronal system, and affect neurotransmission in synapsis.

摘要

在这项药理学研究中,作者对有关肉碱和乙酰肉碱对中枢神经系统活性的现有文献进行了广泛综述。肉碱和乙酰肉碱进入神经内膜系统的神经生化模式,并影响突触中的神经传递。

相似文献

1
A pharmacological profile of the effects of carnitine and acetyl carnitine on the central nervous system.肉碱和乙酰肉碱对中枢神经系统作用的药理学概况。
Int J Clin Pharmacol Res. 1983;3(4):295-306.
2
Physiological effects of acetyl-levo-carnitine in the central nervous system.
Int J Clin Pharmacol Res. 1990;10(1-2):109-14.
3
Effect of gamma-aminobutyric acid on the carnitine metabolism in neural cells.
Biochem Biophys Res Commun. 1995 Aug 15;213(2):383-8. doi: 10.1006/bbrc.1995.2143.
4
Ultrastructural aspects of aging rat hippocampus after long-term administration of acetyl-L-carnitine.
Int J Clin Pharmacol Res. 1990;10(1-2):59-63.
5
[Physiological functions of carnitine and carnitine transporters in the central nervous system].[肉碱及肉碱转运体在中枢神经系统中的生理功能]
Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Jun;28(3):113-20.
6
Effect of L-acetyl carnitine HCl on rat steady-state visual evoked potentials. Comparison with L-carnitine.盐酸L-乙酰肉碱对大鼠稳态视觉诱发电位的影响。与L-肉碱的比较。
Drugs Exp Clin Res. 1987;13(1):5-13.
7
Carnitine and acetylcarnitine in skeletal and cardiac muscle.骨骼肌和心肌中的肉碱与乙酰肉碱。
Int J Vitam Nutr Res. 1978;48(2):177-81.
8
Acetyl-L-carnitine induces a sustained potentiation of the afterhyperpolarization.乙酰左旋肉碱可诱导超极化后电位的持续增强。
Neuroscience. 2004;128(2):293-303. doi: 10.1016/j.neuroscience.2004.06.028.
9
Carnitine transport in rat heart slices: I. The action of thiol reagents on the acetylcarnitine/carnitine exchange.大鼠心脏切片中的肉碱转运:I. 硫醇试剂对乙酰肉碱/肉碱交换的作用。
Ital J Biochem. 1985 Jul-Aug;34(4):275-81.
10
Acetyl-L-carnitine affects nonassociative learning processes in the leech Hirudo medicinalis.乙酰左旋肉碱影响医用水蛭的非联想学习过程。
Neuroscience. 2006 Nov 3;142(4):931-9. doi: 10.1016/j.neuroscience.2006.07.002. Epub 2006 Aug 17.

引用本文的文献

1
Anhedonia and substance dependence: clinical correlates and treatment options.快感缺失与物质依赖:临床关联及治疗选择。
Front Psychiatry. 2011 Mar 17;2:10. doi: 10.3389/fpsyt.2011.00010. eCollection 2011.
2
Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea.乙酰左旋肉碱(ALC)的给予对患有功能性下丘脑性闭经的低促性腺激素性女性的生殖轴有积极影响。
J Endocrinol Invest. 2011 Apr;34(4):287-91. doi: 10.1007/BF03347087. Epub 2010 Apr 22.
3
L-carnitine uptake by mouse brain synaptosomal preparations: competitive inhibition by GABA.
Neurochem Res. 1988 Apr;13(4):317-23. doi: 10.1007/BF00972480.
4
Uptake of acetyl-L-carnitine in the brain.
Neurochem Res. 1989 May;14(5):489-93. doi: 10.1007/BF00964865.
5
Spatial-frequency-dependent changes in the human pattern electroretinogram after acute acetyl-L-carnitine administration.急性给予乙酰左旋肉碱后人类图形视网膜电图的空间频率依赖性变化。
Graefes Arch Clin Exp Ophthalmol. 1991;229(3):262-6. doi: 10.1007/BF00167881.
6
Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo.左旋肉碱和左旋乙酰肉碱对大鼠体内胆碱能感受性新皮质神经元的作用。
J Neural Transm Gen Sect. 1991;86(2):135-46. doi: 10.1007/BF01250574.