The evolution and future horizons of research on the metabolism of arachidonic acid by 5-lipoxygenase.

Leukotrienes have potent biologic actions in various biologic systems. Leukotriene (LT) B4 has inflammatory properties and has been detected in exudates from human inflammatory disease including psoriasis. LTC4, LTD4, and LTE4 have potent bronchoconstrictor actions in vitro and in normal human subjects. LTE4 causes very long-lasting bronchoconstriction. LTC4 and LTD4 are potent vasoconstrictors in coronary and other vascular beds of anesthetized animals. Sulfidopeptide LTs may therefore have a role in asthma and vasospastic disease.