Ford-Hutchinson A, Letts G
Hypertension. 1986 Jun;8(6 Pt 2):II44-9. doi: 10.1161/01.hyp.8.6_pt_2.ii44.
Leukotrienes are novel mediators derived from arachidonic acid through the 5-lipoxygenase enzyme system. Leukotriene B4 has potent effects on leukocyte function and in vivo induces leukocyte accumulation and changes in vascular permeability and modulates pain responses. Peptido-lipid leukotrienes are potent smooth muscle--contracting agents. They may have important cardiovascular actions through mechanisms involving either vasoconstriction or indirect vasodilatation. Evidence for leukotriene production has been found in subjects with allergic conditions and psoriasis, indicating a putative role for these substances in human disease.
白三烯是通过5-脂氧合酶酶系统从花生四烯酸衍生而来的新型介质。白三烯B4对白细胞功能有显著影响，在体内可诱导白细胞聚集、改变血管通透性并调节疼痛反应。肽脂质白三烯是强效的平滑肌收缩剂。它们可能通过涉及血管收缩或间接血管舒张的机制产生重要的心血管作用。在患有过敏性疾病和牛皮癣的受试者中已发现白三烯产生的证据，表明这些物质在人类疾病中可能起作用。
