Bernstein M, Hoffman H J, Halliday W C, Hendrick E B, Humphreys R P
J Neurosurg. 1984 Oct;61(4):649-56. doi: 10.3171/jns.1984.61.4.0649.
The authors review the cases of 60 children (aged 5 months to 18 years) with thalamic tumors who were seen at The Hospital for Sick Children between 1951 and 1983. The diagnosis of thalamic tumor was based on neuroradiological studies; 33 children were first seen in the pre-computerized tomography (CT) era and 27 since the advent of CT scanning. Histological diagnosis was obtained in 37 patients at the time of operation. A further four tumors were verified histologically at autopsy. Thirty-six patients required cerebrospinal fluid shunt placement. Sixteen patients had no surgery on their tumor, three underwent needle biopsy, 20 underwent open biopsy, and 21 had partial resection. Forty-four patients were irradiated. All 20 patients with malignant tumors died, with a mean survival time of 1.1 years. Of 19 patients with benign tumors, 11 died, with a mean survival time of 5.3 years, and eight are still alive after a mean period of 7.2 years since diagnosis. Based on this series, the authors recommend open biopsy of thalamic tumors (and resection if deemed safe), followed by radiation in selected cases.
作者回顾了1951年至1983年间在病童医院就诊的60例丘脑肿瘤患儿（年龄5个月至18岁）的病例。丘脑肿瘤的诊断基于神经放射学研究；33例患儿在计算机断层扫描（CT）时代之前首次就诊，27例自CT扫描出现后首次就诊。37例患者在手术时获得了组织学诊断。另有4例肿瘤在尸检时得到了组织学证实。36例患者需要进行脑脊液分流术。16例患者未对肿瘤进行手术，3例接受了针吸活检，20例接受了开放活检，21例进行了部分切除。44例患者接受了放疗。所有20例恶性肿瘤患者均死亡，平均生存时间为1.1年。19例良性肿瘤患者中，11例死亡，平均生存时间为5.3年，8例自诊断后平均7.2年仍存活。基于这一系列病例，作者建议对丘脑肿瘤进行开放活检（若认为安全则进行切除），随后在特定病例中进行放疗。
