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人体肝动脉栓塞后动脉血中乙酰乙酸/β-羟基丁酸比值的变化

Changes in acetoacetate/beta-hydroxybutyrate ratio in arterial blood following hepatic artery embolization in man.

作者信息

Tani T, Taki Y, Aoyama H, Jikkoh A, Arii S, Ozawa K, Tobe T

出版信息

Life Sci. 1984 Sep 10;35(11):1177-82. doi: 10.1016/0024-3205(84)90188-7.

DOI:10.1016/0024-3205(84)90188-7
PMID:6088925
Abstract

Acetoacetate/beta-hydroxybutyrate ratio in the hepatic venous blood was compared to the ratios in arterial blood and peripheral venous blood in hypoxic state following right hepatic artery embolization in 5 patients with liver cancer. Ketone body ratios in right hepatic venous blood were positively correlated with those in arterial blood (r = 0.960, p less than 0.001), but not with those in peripheral venous blood. The free NAD+/NADH ratio of the liver mitochondria, which is reflected by the ketone body ration in hepatic venous blood, can be evaluated by the ketone body ratio in the arterial blood.

摘要

对5例肝癌患者右肝动脉栓塞后低氧状态下肝静脉血中乙酰乙酸/β-羟基丁酸比值与动脉血和外周静脉血中的比值进行了比较。右肝静脉血中的酮体比值与动脉血中的酮体比值呈正相关(r = 0.960,p < 0.001),但与外周静脉血中的酮体比值无相关性。肝静脉血中酮体比值所反映的肝脏线粒体游离NAD+/NADH比值可通过动脉血中的酮体比值进行评估。

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