Young A B, Pan H S, Ciliax B J, Penney J B
Neurosci Lett. 1984 Jun 29;47(3):361-7. doi: 10.1016/0304-3940(84)90540-8.
GABA and its associated benzodiazepine interactions play an important role in basal ganglia function. Distinctive GABA, benzodiazepine and opiate receptor changes occur in response to striatal lesions and in the human neurodegenerative disorder, Huntington's disease (HD). In animal experiments, the in vivo administration of [3H]flunitrazepam labels benzodiazepine receptors and can demonstrate the receptor changes seen after striatal lesions. It should be possible to measure these receptors in vivo in humans using positron-emission tomographic scanning.
γ-氨基丁酸（GABA）及其相关的苯二氮䓬相互作用在基底神经节功能中起重要作用。纹状体损伤以及人类神经退行性疾病亨廷顿舞蹈症（HD）会引发独特的GABA、苯二氮䓬和阿片受体变化。在动物实验中，体内注射[3H]氟硝西泮可标记苯二氮䓬受体，并能显示纹状体损伤后出现的受体变化。利用正电子发射断层扫描技术应该能够在人体内对这些受体进行活体测量。
