Semin Iu A, Shevchuk A S, Dubovik B V
Radiobiologiia. 1984 Jul-Aug;24(4):476-80.
The radioactive ligands, [3H]dihydroalprenolol and [3H]muscimol, were used to estimate the condition of beta-adrenoreceptors of the brain cortex and GABA-receptors of the cerebellum during transient neurologic disorders caused by irradiation of rats with high-energy (20 MeV) electrons of 200 Gy. No significant changes were observed in the GABA-ergic brain system while the changes in beta-adrenoreceptors of the brain were pronounced and manifested by the loss by the receptors of their ability to bind the specific ligand, dihydroalprenolol. The changes observed were reversible and correlated with the development of neurologic disorders.
使用放射性配体[³H]二氢阿普洛尔和[³H]蝇蕈醇，来评估在200 Gy的高能（20 MeV）电子辐照大鼠引起的短暂性神经功能障碍期间，大脑皮层β-肾上腺素能受体和小脑GABA受体的状况。在GABA能脑系统中未观察到明显变化，而大脑β-肾上腺素能受体的变化则很明显，表现为受体失去结合特异性配体二氢阿普洛尔的能力。观察到的这些变化是可逆的，并且与神经功能障碍的发展相关。
