Riederer S J, Suddarth S A, Bobman S A, Lee J N, Wang H Z, MacFall J R
Radiology. 1984 Oct;153(1):203-6. doi: 10.1148/radiology.153.1.6089265.
The authors describe an automated technique of magnetic resonance (MR) image synthesis. Given a specific pulse sequence, MR signals are acquired for several pulse delay and/or repetition times and used to compute images of intrinsic parameters T1, T2, and N(H). Both the computed images and operator-specified pulse delay and repetition times are then used to "synthesize" a new image based on equations descriptive of MR signal behavior and comparable to that acquired by using the operator-specified parameters in an actual MR study. Instrumentation enabling rapid operator-interactive generation of synthesized images is described and initial results presented, allowing for dependence of the signal on T2 in spin echo images. Extension to full T1, T2, and N(H) dependence for arbitrary pulse sequences is described. Major advantages of this technique include retrospective optimization of contrast between arbitrary materials, rapid and systematic image analysis, and reduced scanning time; potential limitations include accuracy, noise, motion artifacts, and multicomponent behavior.
作者描述了一种磁共振（MR）图像合成的自动化技术。给定特定的脉冲序列，采集多个脉冲延迟和/或重复时间的MR信号，并用于计算固有参数T1、T2和N(H)的图像。然后，基于描述MR信号行为的方程，将计算出的图像以及操作员指定的脉冲延迟和重复时间用于“合成”新图像，该新图像与在实际MR研究中使用操作员指定参数采集的图像相当。描述了能够实现快速操作员交互式生成合成图像的仪器，并展示了初步结果，结果表明自旋回波图像中的信号依赖于T2。还描述了将该技术扩展到任意脉冲序列的完整T1、T2和N(H)依赖情况。该技术的主要优点包括对任意材料之间对比度的回顾性优化、快速系统的图像分析以及减少扫描时间；潜在的局限性包括准确性、噪声、运动伪影和多组分行为。
