磷酸乙醇酸磷酸酶（PGP）-触珠蛋白α（HPA）连接中可能存在的异质性。
Possible heterogeneity in the phosphoglycolate phosphatase (PGP)-haptoglobin alpha (HPA) linkage.
作者信息
Bale S J, Chakravarti A, Ferrell R E, Spence M A
出版信息
Am J Hum Genet. 1984 Jul;36(4):808-14.
Previous investigators have reported loose linkage in both sexes for phosphoglycolate phosphatase (PGP) and haptoglobin alpha (HPA). We present results of linkage studies between PGP and HPA in two data sets, one from Houston and the other an update of an earlier report from Los Angeles. Using quadratic interpolation to estimate the male (theta m) and female (theta f) recombination values from bivariate lod tables, we found for the Houston data that theta m = 0.43 and theta f = 0.03 at the maximum lod score of z = 2.23. For the Los Angeles series, we found that theta m = 0.31, theta f = 0.48, and z = 0.27. We invoke heterogeneity in the recombination value in different families as an explanation of our findings. We also recommend that bivariate lod tables should always be generated, even though not reported. This is because the usual assumption of theta m = theta f (and, rarely, theta f = 1.8 theta f) under which lod scores are computed may be invalid in many cases.
先前的研究人员报告了磷酸乙醇酸磷酸酶（PGP）和触珠蛋白α（HPA）在两性中存在松散连锁。我们展示了在两个数据集中PGP和HPA之间连锁研究的结果，一个数据集来自休斯顿，另一个是洛杉矶早期报告的更新版本。使用二次插值法从双变量对数优势表估计男性（θm）和女性（θf）的重组值，我们发现对于休斯顿数据集，在最大对数优势分数z = 2.23时，θm = 0.43且θf = 0.03。对于洛杉矶系列，我们发现θm = 0.31，θf = 0.48，且z = 0.27。我们将不同家族中重组值的异质性作为我们研究结果的一个解释。我们还建议即使不报告，也应始终生成双变量对数优势表。这是因为计算对数优势分数时通常假设的θm = θf（很少情况下，θf = 1.8θf）在许多情况下可能无效。
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