Hiroshi K, Masanori O, Kaoru A, Gompachi Y, Hiroshi S
Gan To Kagaku Ryoho. 1984 Aug;11(8):1598-604.
The effect of 6-keto-prostaglandin E1 which has a potential action for antiplatelet aggregation was investigated against AH-130 in vivo in comparison with mitomycin C. The experimental schemes were as follows: Group I: Control, Group II: Thromboxane B2 (0.5 mg/kg, X 8, iv), Group III: 6-keto-PG-E1 (0.5 mg/kg, X 10, iv), Group IV: MMC (1.5 mg/kg, X 1, ip), Group V: 6-keto-PGE1 + MMC (0.5 mg/kg, X 10, iv, + 1.5 mg/kg, X 1, ip). The mean survival days, median survival day, and ILS% for 60 days disclosed an inhibitory effect of 6-keto-PGE1, 6-keto-PGE1 + MMC on AH-130 tumor cell growth. By contrast, TXB2, had a promoting effect on AH-130 tumor cell growth. It is concluded that 6-keto-PGE1 which has a structure activity relationship with antitumor agents, such as MMC, Diketocoriolin B, etc., played an important inhibitory role in tumor cell growth in AH-130 in vivo, particularly in combination with the antitumor agents, MMC.
研究了具有抗血小板聚集潜在作用的6-酮-前列腺素E1与丝裂霉素C相比在体内对AH-130的作用。实验方案如下：第一组：对照组；第二组：血栓素B2（0.5mg/kg，静脉注射，共8次）；第三组：6-酮-前列腺素E1（0.5mg/kg，静脉注射，共10次）；第四组：丝裂霉素C（1.5mg/kg，腹腔注射，共1次）；第五组：6-酮-前列腺素E1+丝裂霉素C（0.5mg/kg，静脉注射，共10次，+1.5mg/kg，腹腔注射，共1次）。60天的平均存活天数、中位存活天数和ILS%显示6-酮-前列腺素E1、6-酮-前列腺素E1+丝裂霉素C对AH-130肿瘤细胞生长有抑制作用。相比之下，血栓素B2对AH-130肿瘤细胞生长有促进作用。得出结论，与丝裂霉素C、双酮蓖麻毒素B等抗肿瘤药物具有结构活性关系的6-酮-前列腺素E1在体内对AH-130肿瘤细胞生长起重要抑制作用，特别是与抗肿瘤药物丝裂霉素C联合使用时。
