Suzuki M
Nihon Geka Gakkai Zasshi. 1986 Jan;87(1):10-9.
We conducted an experimental animal study to make a comparative evaluation of therapeutic effects of plasma exchange alone and combination therapy. The subjects of this study were divided into four groups: (1) untreated group (control). (2) plasma exchange group (PE). (3) Mitomycin C treated group (MMC: active control) and (4) plasma exchange + MMC treated group (combination therapy). A tumor inhibiting effect was observed in the MMC and combination therapy groups, but was absent in the PE group. The survival-periods, however, were extended in the PE group, and to a significant extent in the combination therapy group. Alpha 1 acid glycoprotein (alpha 1 AGP) whose plasma level is low in the normal, is demonstrated to increase linealy with the tumor load in the plasma of cancer-bearing rats. And it is observed to decreased after plasma exchange. Present basic studies suggested that plasma exchange alone has a survival-prolonging effect, but produces no inhibitory effect on tumor growth, and the combination therapy has a greater life-extending effect than plasma exchange alone or chemotherapy alone.
我们进行了一项实验动物研究，以对单独血浆置换疗法和联合疗法的治疗效果进行比较评估。本研究的对象分为四组：（1）未治疗组（对照组）。（2）血浆置换组（PE）。（3）丝裂霉素C治疗组（MMC：阳性对照组）和（4）血浆置换+MMC治疗组（联合疗法）。在MMC组和联合治疗组中观察到了肿瘤抑制作用，但在PE组中未观察到。然而，PE组的生存期延长了，联合治疗组的生存期则有显著延长。α1酸性糖蛋白（α1AGP）在正常情况下血浆水平较低，已证明其在荷癌大鼠血浆中随肿瘤负荷呈线性增加。并且观察到在血浆置换后其水平下降。目前的基础研究表明，单独血浆置换有延长生存期的作用，但对肿瘤生长没有抑制作用，联合疗法比单独血浆置换或单独化疗具有更大的延长生命的作用。
