Caredda F, d'Arminio Monforte A, Rossi E, Zampini L, Lazzarin A, Moroni M
Boll Ist Sieroter Milan. 1984 Mar;63(1):34-6.
Sixty-nine consecutive patients with acute type A hepatitis were followed-up to establish the natural history of the disease. Illicit drug abusers were not included in this study. 19% (13/69) of the patients at 6th month, and 6% (4/69) at 12th month showed aminotransferase (ALT) values at least two folds the upper levels. The histological examinations performed in 5 of these cases suggest that persistence of abnormal ALT levels may be related to a misdiagnosed chronic liver disease preexisting the acute type A hepatitis. Three of the 69 patients had a relapsing hepatitis with two peaks of serum ALT 6-8 weeks apart. The illness resolved uneventfully in all these patients. The exclusion of exposure to liver toxins such as alcohol or drugs, as well as other known hepatitis virus infection in these cases, suggests that the two distinct episodes of hepatitis could be the result of the sequential infection of hepatitis A and non-A, non-B viruses.
对69例连续性急性甲型肝炎患者进行随访以明确该疾病的自然病程。本研究未纳入非法药物滥用者。6个月时19%（13/69）的患者以及12个月时6%（4/69）的患者转氨酶（ALT）值至少为正常上限的两倍。对其中5例患者进行的组织学检查提示，ALT水平异常持续存在可能与急性甲型肝炎之前误诊的慢性肝病有关。69例患者中有3例出现复发性肝炎，血清ALT有两个峰值，间隔6 - 8周。所有这些患者病情均顺利缓解。排除这些病例中酒精或药物等肝毒素暴露以及其他已知的肝炎病毒感染因素后，提示这两起不同的肝炎发作可能是甲型肝炎病毒和非甲非乙型病毒先后感染的结果。
