Prescott R W, Ratcliffe W A, Taylor P K
Br Med J (Clin Res Ed). 1984 Sep 29;289(6448):787-8. doi: 10.1136/bmj.289.6448.787.
A study was performed to see whether ketanserin, a serotonin antagonist, would reduce the raised concentrations of adrenocorticotrophic hormone (ACTH) in patients with Nelson's syndrome. Six patients who had undergone bilateral adrenalectomy for Cushing's disease and who had Nelson's syndrome were given ketanserin 40 mg twice daily and placebo, for at least two months each, in a double blind crossover study. Ketanserin had no effect on ACTH concentrations. In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome. These results show that it is not indicated in these patients.
进行了一项研究，以观察5-羟色胺拮抗剂酮色林是否会降低尼尔森综合征患者升高的促肾上腺皮质激素（ACTH）浓度。在一项双盲交叉研究中，对6例因库欣病接受双侧肾上腺切除术且患有尼尔森综合征的患者，每日两次给予40mg酮色林和安慰剂，每种药物至少服用两个月。酮色林对ACTH浓度没有影响。在健康人中，5-羟色胺似乎在ACTH分泌调节中起刺激作用，且酮色林降低ACTH对低血糖反应的作用表明它可能对尼尔森综合征有用。这些结果表明，在这些患者中不适用。
