大鼠脑蛙皮素样肽及其受体的发育
The development of rat brain bombesin-like peptides and their receptors.
作者信息
Gillati M T, Moody T W
出版信息
Brain Res. 1984 Aug;317(2):286-9. doi: 10.1016/0165-3806(84)90107-x.
PMID:6089970
Abstract
The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maximal in all brain regions examined by the second postnatal week. These data indicate that the development of receptors precede bombesin-like peptide production.
摘要
在9个不同的大鼠脑区中测定了蛙皮素样肽及其受体的发育情况。在出生后的第三周，在所检测的所有脑区中，免疫反应性蛙皮素的浓度急剧增加。相比之下，在出生后的第二周，在所检测的所有脑区中，[125I-Tyr4]蛙皮素结合位点的密度接近最大值。这些数据表明，受体的发育先于蛙皮素样肽的产生。
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