Moody T W, Bertness V, Carney D N
Peptides. 1983 Sep-Oct;4(5):683-6. doi: 10.1016/0196-9781(83)90018-9.
Human cancer cell lines were assayed for bombesin-like peptides and receptors. Acid extracts derived from small cell lung cancer, but not other types of cancer had high levels of immunoreactive bombesin. Regardless of patient treatment, site of tumor origin (bone marrow, lymph node, or pleural effusion) or culture conditions, small cell lung cancer cell lines had high levels of bombesin-like peptides. Thus, bombesin levels in small cell lung, but not other types of human cancer, are routinely elevated. Also, small cell lung cancer lines in contrast to other cell lines have a high density of binding sites for a radiolabeled bombesin analogue. The presence of high concentrations of bombesin-like peptides and receptors suggests that bombesin may function as an important regulatory agent in human small cell lung cancer.
对人类癌细胞系进行了蛙皮素样肽和受体检测。从小细胞肺癌提取的酸性提取物中含有高水平的免疫反应性蛙皮素，而其他类型癌症的提取物中则没有。无论患者的治疗情况、肿瘤起源部位（骨髓、淋巴结或胸腔积液）或培养条件如何，小细胞肺癌细胞系都含有高水平的蛙皮素样肽。因此，小细胞肺癌中的蛙皮素水平通常会升高，而其他类型的人类癌症则不会。此外，与其他细胞系相比，小细胞肺癌细胞系对放射性标记的蛙皮素类似物具有高密度的结合位点。高浓度的蛙皮素样肽和受体的存在表明，蛙皮素可能在人类小细胞肺癌中作为一种重要的调节因子发挥作用。
