4-（二甲基氨基）偶氮苯羟甲基衍生物在大鼠、小鼠和仓鼠肝脏中的致癌活性。
Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters.
作者信息
Mori Y, Niwa T, Toyoshi K, Nagai H, Koda A, Kawada K, Ojima A, Konishi Y
出版信息
Exp Pathol. 1984;26(1):15-9. doi: 10.1016/s0232-1513(84)80064-x.
The carcinogenic activity of 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) was studied in Sprague-Dawley rats of both sexes, male ddy mice, and male Syrian golden hamsters. The activity of 2'-CH2OH-DAB and 4'-CH2OH-DAB was studied in male Sprague-Dawley rats. Azo dyes were given in the diet at a concentration of 0.064% for 3 months followed by a stock diet for 1 month; animals were sacrificed 4 months after beginning of the experiment. Liver hyperplastic nodules developed in all 8 male rats (100%) and in all 10 female rats (100%) which received 3'-CH2OH-DAB and in 7 out of 12 male rats (58%) which received 2'-CH2OH-DAB. Hepatocellular carcinomas were produced in 1 out of 8 male rats (13%) and in 1 out of 10 female rats (10%) receiving 3'-CH2OH-DAB. No hepatic lesions were observed in rats receiving 4'-CH2OH-DAB and in mice and hamsters receiving 3'-CH2OH-DAB. These results indicate that a carcinogenic effect of 3'-CH2OH-DAB and 2'-CH2OH-DAB could be detected in rats.
研究了3'-羟甲基-N,N-二甲基-4-氨基偶氮苯（3'-CH2OH-DAB）对雄性和雌性斯普拉格-道利大鼠、雄性ddy小鼠以及雄性叙利亚金仓鼠的致癌活性。研究了2'-CH2OH-DAB和4'-CH2OH-DAB对雄性斯普拉格-道利大鼠的活性。偶氮染料以0.064%的浓度添加到饲料中，持续3个月，之后给予基础饲料1个月；在实验开始4个月后处死动物。接受3'-CH2OH-DAB的所有8只雄性大鼠（100%）和所有10只雌性大鼠（100%）以及接受2'-CH2OH-DAB的12只雄性大鼠中的7只（58%）出现了肝脏增生性结节。接受3'-CH2OH-DAB的8只雄性大鼠中有1只（13%）和10只雌性大鼠中有1只（10%）发生了肝细胞癌。接受4'-CH2OH-DAB的大鼠以及接受3'-CH2OH-DAB的小鼠和仓鼠未观察到肝脏病变。这些结果表明，在大鼠中可检测到3'-CH2OH-DAB和2'-CH2OH-DAB的致癌作用。
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