Hirokawa K, Utsuyama M, Goto H, Kuramoto K
Gerontology. 1984;30(4):223-33. doi: 10.1159/000212636.
Immunological studies were performed in aging C57BL/6 and BDF1 mice. In C57BL/6 mice the incidence of malignant tumor was high and their mean life span was 665 days in males and 649 days in females. In BDF1 mice, the incidence of malignant tumors was significantly lower, and their mean life span was 954 days in males and 846 days in females. Immunologically, either the onset of decline occurred earlier, the rate of the age-related decline in activity was more rapid, and/or the magnitude of decline was greater in the shorter-lived C57BL/6 than in the longer-lived BDF1 mice. The close relationship between (a) the susceptibility especially to malignant lymphoma; (b) the onset, rate and magnitude of age-related decline in T-cell-dependent immunologic activities, and (c) the life span would suggest that T-cell immunity may be playing an important role in the resistance against life-shortening malignant lymphoma in C57BL/6 mice.
在衰老的C57BL/6和BDF1小鼠中进行了免疫学研究。在C57BL/6小鼠中，恶性肿瘤的发生率很高，其平均寿命在雄性中为665天，在雌性中为649天。在BDF1小鼠中，恶性肿瘤的发生率显著较低，其平均寿命在雄性中为954天，在雌性中为846天。在免疫学方面，与寿命较短的C57BL/6小鼠相比，寿命较长的BDF1小鼠要么衰退开始得更早，与年龄相关的活性下降速率更快，和/或下降幅度更大。（a）对恶性淋巴瘤的易感性；（b）T细胞依赖性免疫活性与年龄相关的衰退的开始、速率和幅度；以及（c）寿命之间的密切关系表明，T细胞免疫可能在C57BL/6小鼠抵抗缩短寿命的恶性淋巴瘤中发挥重要作用。
