Cheney K E, Liu R K, Smith G S, Meredith P J, Mickey M R, Walford R L
J Gerontol. 1983 Jul;38(4):420-30. doi: 10.1093/geronj/38.4.420.
Seven groups of mice were maintained on different dietary programs varying with respect to restriction at various stages of life. Restriction was associated with less age-related decline in T-dependent immunological function and a slight but significant lowering of body temperature. The best mean and maximum survival and the lowest late-life mortality rate was found in the group restricted throughout life, but restriction during any part of the lifespan enhanced survival to some degree. The mean life spans of tumor-bearing animals tended to be greater in restricted than in nonrestricted groups, corresponding to an age-decelerating effect. Tumor frequency varied with the period of life during which restriction took place and was not always decreased in restricted animals. These latter results suggest that the mechanisms whereby dietary restriction influences the aging rate and tumor susceptibility may not be entirely identical.
七组小鼠按照不同的饮食方案饲养，这些方案在生命的不同阶段有着不同程度的限制。限制饮食与T细胞依赖性免疫功能随年龄增长的衰退减缓以及体温的轻微但显著降低有关。终生受限组的平均和最大生存期最佳，晚年死亡率最低，但在生命周期的任何阶段进行限制都能在一定程度上提高生存率。与未受限组相比，受限的荷瘤动物平均寿命往往更长，这对应着一种年龄减缓效应。肿瘤发生率随限制饮食发生的生命阶段而变化，在受限动物中并不总是降低。后一组结果表明，饮食限制影响衰老速度和肿瘤易感性的机制可能并不完全相同。
