人绒毛膜促性腺激素受体介导的内吞作用过程中激素-受体复合物在溶酶体中的积累。
Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin.
作者信息
Ascoli M
出版信息
J Cell Biol. 1984 Oct;99(4 Pt 1):1242-50. doi: 10.1083/jcb.99.4.1242.
Abstract
The experiments presented herein were designed to determine the fate of the human choriogonadotropin (hCG) receptor during endocytosis of the receptor-bound hCG. Using several biochemical approaches, it is shown that the receptor is internalized together with the hormone into endocytic vesicles and transferred to lysosomes without ligand dissociation. Once delivered to the lysosomes, the hCG-receptor complex dissociates, and the free hormone is degraded. This pathway appears to prevent receptor recycling and probably promotes receptor degradation.
摘要
本文所呈现的实验旨在确定人绒毛膜促性腺激素（hCG）受体在与受体结合的hCG内吞过程中的命运。通过几种生化方法表明，该受体与激素一起被内化到内吞小泡中，并在没有配体解离的情况下转移到溶酶体。一旦被递送到溶酶体，hCG-受体复合物就会解离，游离的激素被降解。这条途径似乎阻止了受体的再循环，并且可能促进了受体的降解。
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本文引用的文献
1
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Methods Enzymol. 1980;65(1):363-71. doi: 10.1016/s0076-6879(80)65047-2.
2
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.胰岛素诱导的培养人淋巴细胞中的受体丢失是由于受体降解加速所致。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6917-21. doi: 10.1073/pnas.78.11.6917.
3
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis.受体介导的吞噬作用过程中巨噬细胞Fc受体的内化与降解
J Cell Biol. 1983 Mar;96(3):887-95. doi: 10.1083/jcb.96.3.887.
4
Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.对毒素和病毒“交叉耐药”的中国仓鼠卵巢细胞突变体中内体酸化缺陷。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5315-9. doi: 10.1073/pnas.80.17.5315.
5
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7
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9
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10
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