Comparison between the properties of the vagal and splanchnic glucoreceptors of the small intestine. Involvement in insulin release.

It was recently well established that the vagal intestinal glucoreceptors are involved in insulin release. In this work we demonstrate that the splanchnic glucoreceptors play a unique role in insulin release: their activation induces a decrease, like strong mechanical stimulation. The physiological meaning of this effect is not clear, it may be a non-physiological response, because high glucose concentration is abnormal in the jejuno-ileal lumen. This work represents the first comparison between the properties and role of different kinds of glucoreceptors.