Mei N, Arlhac A, Boyer A
J Auton Nerv Syst. 1981 Nov;4(4):351-63. doi: 10.1016/0165-1838(81)90038-2.
In anesthetized cats and rats, it is demonstrated that glucose perfusion of the small intestine produces a rapid increase of insulin secretion (IRI) which precedes glycemia variation. This mechanism involves the autonomic nervous system and originates from intestinal glucoreceptors, the existence of which was recently reported. The nervous pathways are described in this study:(1) the afferent pathway is represented by vagal fibers coming from the intestinal glucoreceptors; (2) the efferent pathway involves both sympathetic fibers (splanchnic nerves) and chiefly parasympathetic fibers (vagal nerves). These results are established after surgical suppression of afferent and efferent vagal fibers, and pharmacological exclusion of parasympathetic or sympathetic fibers. The role of this nervous regulation of insulin secretion is discussed with special reference to other already known mechanisms.
在麻醉的猫和大鼠中，已证实小肠葡萄糖灌注会使胰岛素分泌（IRI）迅速增加，且该增加先于血糖变化。这一机制涉及自主神经系统，起源于肠道葡萄糖受体，其存在最近已有报道。本研究描述了神经通路：（1）传入通路由来自肠道葡萄糖受体的迷走神经纤维代表；（2）传出通路涉及交感神经纤维（内脏神经）和主要的副交感神经纤维（迷走神经）。这些结果是在手术切断传入和传出迷走神经纤维以及通过药理学方法排除副交感或交感神经纤维后得出的。本文特别参照其他已知机制讨论了这种胰岛素分泌神经调节的作用。
