老年及阿尔茨海默病中淋巴细胞β-肾上腺素能刺激的腺苷酸环化酶的急性脱敏作用
Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease.
作者信息
Oppenheim G, Mintzer J, Halperin Y, Eliakim R, Stessman J, Ebstein R P
出版信息
Life Sci. 1984 Oct 22;35(17):1795-802. doi: 10.1016/0024-3205(84)90277-7.
PMID:6090850
Abstract
The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.
摘要
研究了在37℃下用单一浓度的异丙肾上腺素（10⁻⁴M）预孵育2小时，对来自年轻人、老年人以及阿尔茨海默病患者的完整淋巴细胞中异丙肾上腺素刺激的环磷酸腺苷（cAMP）积累的影响。在所有三个受试者组的淋巴细胞中，用异丙肾上腺素预孵育细胞后，随后再用异丙肾上腺素刺激时，cAMP积累显著减少。
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