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阿尔茨海默病:异丙肾上腺素和前列腺素E1刺激淋巴细胞中环磷酸腺苷的积累。

Alzheimer's disease: isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes.

作者信息

Ebstein R P, Oppenheim G, Stessman J

出版信息

Life Sci. 1984 Jun 4;34(23):2239-43. doi: 10.1016/0024-3205(84)90211-x.

DOI:10.1016/0024-3205(84)90211-x
PMID:6145077
Abstract

Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E1 receptor activity was seen in the aged controls. In the Alzheimer patients, however, such lymphocytic prostaglandin E1 receptor activity was significantly raised and correlated with a rating scale for severity of dementia.

摘要

在阿尔茨海默病患者和老年对照组中均观察到淋巴细胞β-肾上腺素能受体活性降低;在老年对照组中,淋巴细胞前列腺素E1受体活性也呈平行下降。然而,在阿尔茨海默病患者中,这种淋巴细胞前列腺素E1受体活性显著升高,且与痴呆严重程度评分量表相关。

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Alzheimer's disease: isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes.阿尔茨海默病:异丙肾上腺素和前列腺素E1刺激淋巴细胞中环磷酸腺苷的积累。
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引用本文的文献

1
Hormone and forskolin-stimulated cyclic AMP accumulation in human lymphocytes: reliability of longitudinal time measurements.激素和福斯高林刺激下人淋巴细胞中环磷酸腺苷的积累:纵向时间测量的可靠性
Experientia. 1986 Jul 15;42(7):838-41. doi: 10.1007/BF01941546.
2
Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes.正常及EB病毒转化淋巴细胞中β-肾上腺素能刺激的腺苷酸环化酶活性
Experientia. 1985 Dec 15;41(12):1552-4. doi: 10.1007/BF01964803.