阿尔茨海默病：异丙肾上腺素和前列腺素E1刺激淋巴细胞中环磷酸腺苷的积累。
Alzheimer's disease: isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes.
作者信息
Ebstein R P, Oppenheim G, Stessman J
出版信息
Life Sci. 1984 Jun 4;34(23):2239-43. doi: 10.1016/0024-3205(84)90211-x.
PMID:6145077
Abstract
Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E1 receptor activity was seen in the aged controls. In the Alzheimer patients, however, such lymphocytic prostaglandin E1 receptor activity was significantly raised and correlated with a rating scale for severity of dementia.
摘要
在阿尔茨海默病患者和老年对照组中均观察到淋巴细胞β-肾上腺素能受体活性降低；在老年对照组中，淋巴细胞前列腺素E1受体活性也呈平行下降。然而，在阿尔茨海默病患者中，这种淋巴细胞前列腺素E1受体活性显著升高，且与痴呆严重程度评分量表相关。
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