Davelaar F G, Kouwenhoven B, Burger A G
Vet Q. 1984 Jul;6(3):114-20. doi: 10.1080/01652176.1984.9693924.
Despite vaccination against Infectious bronchitis virus (IBV) with the Massachusetts type vaccine viruses H120 and H52 in the Netherlands, an increasing number of properly vaccinated flocks have suffered from the disease since 1978. In the years 1978-1982, the virus was isolated from 162 IBV suspected flocks. Cross-virus-neutralization tests showed that the majority (67 per cent) of these isolates belonged to serotypes other than the Massachusetts type, the Connecticut-, Florida-, Iowa 97-, Iowa 609- and JMK serotype. The majority of these Dutch isolates could be divided into 4 serogroups, called D207, D212, D3128 and D3896. Only a few isolates were not related to these serotypes. A survey of 328 flocks for antibody against these serotypes demonstrated that antibody against one or more of these novel serotypes were present in most of the flocks. Experiments demonstrated that vaccination with the H120 vaccine virus was not able to protect chickens against the adverse effects of a challenge with the novel serotypes.
尽管荷兰使用马萨诸塞型疫苗病毒H120和H52对传染性支气管炎病毒（IBV）进行了疫苗接种，但自1978年以来，越来越多接种过疫苗的鸡群感染了这种疾病。在1978 - 1982年期间，从162个疑似感染IBV的鸡群中分离出了病毒。交叉病毒中和试验表明，这些分离株中的大多数（67%）属于马萨诸塞型以外的血清型，即康涅狄格型、佛罗里达型、爱荷华97型、爱荷华609型和JMK血清型。这些荷兰分离株中的大多数可分为4个血清群，分别称为D207、D212、D3128和D3896。只有少数分离株与这些血清型无关。对328个鸡群进行的针对这些血清型抗体的调查表明，大多数鸡群中都存在针对一种或多种这些新血清型的抗体。实验表明，用H120疫苗病毒进行疫苗接种并不能保护鸡免受新血清型攻击的不利影响。
