人巨细胞病毒对腺病毒5型即刻早期突变体的互补作用。
Complementation of an adenovirus 5 immediate early mutant by human cytomegalovirus.
作者信息
Tevethia M J, Spector D J
出版信息
Virology. 1984 Sep;137(2):428-31. doi: 10.1016/0042-6822(84)90236-8.
PMID:6091338
Abstract
The initiation of the lytic cycle of adenovirus 5 requires synthesis of a transcriptional activator encoded by the viral early genetic unit, E1a. Mutant viruses lacking E1a are defective. Human cytomegalovirus activated transcription of early adenovirus genes and complemented an E1a- adenovirus mutant in cells permissive for both viruses.
摘要
腺病毒5型裂解周期的启动需要合成一种由病毒早期遗传单位E1a编码的转录激活因子。缺乏E1a的突变病毒存在缺陷。人巨细胞病毒激活了腺病毒早期基因的转录，并在对两种病毒均敏感的细胞中互补了E1a缺陷型腺病毒突变体。
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