Kimelman D, Miller J S, Porter D, Roberts B E
J Virol. 1985 Feb;53(2):399-409. doi: 10.1128/JVI.53.2.399-409.1985.
Simian adenovirus 7 (SA7) is a highly oncogenic virus, capable of causing tumors in hamsters upon the direct injection of viral DNA. We determined the transcriptional organization of the transforming region and compared it with that of the human adenoviruses. This analysis demonstrated that there are two independently promoted transcription units similar to the E1a and E1b regions of the human adenoviruses. The nucleotide sequence of the SA7 E1a region demonstrated considerable homology with the human adenoviruses, both in the sequences that regulate E1a expression and in the encoded polypeptides. The amino acid homology was reflected in the ability of SA7 to complement the growth of human adenoviruses mutant in the E1a region. Furthermore, we found two regions of amino acid homology unique to SA7 and the highly oncogenic human adenovirus 12.
猿猴腺病毒7（SA7）是一种高度致癌的病毒，直接注射病毒DNA后能够在仓鼠体内引发肿瘤。我们确定了转化区的转录组织，并将其与人类腺病毒的转录组织进行了比较。该分析表明，存在两个独立启动的转录单元，类似于人类腺病毒的E1a和E1b区域。SA7 E1a区域的核苷酸序列在调节E1a表达的序列和编码的多肽方面都与人类腺病毒表现出相当高的同源性。氨基酸同源性体现在SA7能够互补E1a区域突变的人类腺病毒的生长。此外，我们发现了SA7和高度致癌的人类腺病毒12特有的两个氨基酸同源区域。
