Prescott M F, Müller K R, Flammer R, Feige U
Agents Actions Suppl. 1984;16:163-70. doi: 10.1007/978-3-0348-7235-5_19.
The role that lipid uptake might play in macrophage activation was investigated using mouse peritoneal macrophages in vitro. Incubation with acetylated LDL for 48 hours resulted in a 12 fold increase in cholesterol ester content in macrophages; incubation with oxidized LDL resulted in a 6 fold increase in cholesterol ester, while incubation with native LDL did not result in cholesterol accumulation. Incubation of macrophages with acetylated LDL or oxidized LDL produced no change in macrophage production of plasminogen activator or secretion of interleukin 1 or superoxide anion.
利用小鼠腹腔巨噬细胞在体外研究了脂质摄取在巨噬细胞激活中可能发挥的作用。用乙酰化低密度脂蛋白孵育48小时导致巨噬细胞中胆固醇酯含量增加12倍；用氧化低密度脂蛋白孵育导致胆固醇酯增加6倍，而用天然低密度脂蛋白孵育未导致胆固醇积累。用乙酰化低密度脂蛋白或氧化低密度脂蛋白孵育巨噬细胞不会改变巨噬细胞纤溶酶原激活物的产生或白细胞介素1或超氧阴离子的分泌。
